کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4001462 1259410 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical implications of hypoxia inducible factor in renal cell carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Clinical implications of hypoxia inducible factor in renal cell carcinoma
چکیده انگلیسی

Management of renal cell carcinoma (RCC) has made considerable strides in the past decade, due in large part to identification of the von Hippel Lindau (VHL) tumor suppressor as a negative regulator of hypoxia inducible factor α (HIF-α) protein expression. Stabilization of HIF-α appears to be critical for renal tumorigenesis, and is observed even in VHL-independent RCC. Thus, an understanding of the pathways that regulate expression and activation of the different HIF-α isoforms is key to delineating the mechanism of renal transformation and for the development of novel therapeutics. A number of agents targeting HIF-α or its transcriptionally-regulated genes have shown promise in treatment of RCC. However, more effective treatment strategies are still needed. This report provides a directed review of recent discoveries defining the role of HIF in renal tumorigenesis and their relevance to the clinical advances in targeted therapy for advanced RCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 27, Issue 3, May–June 2009, Pages 238–245
نویسندگان
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