کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4061334 1604017 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Zoledronic Acid on Reducing Femoral Bone Mineral Density Loss following Total Hip Arthroplasty : Preliminary Results of a Prospective Randomized Trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Effect of Zoledronic Acid on Reducing Femoral Bone Mineral Density Loss following Total Hip Arthroplasty : Preliminary Results of a Prospective Randomized Trial
چکیده انگلیسی

This randomized trial evaluated the effect of zoledronic acid on femoral bone mineral density (BMD) following primary total hip arthroplasty. Bone mineral density was compared for up to 2 years in 27 patients receiving 5 mg zoledronic acid intravenous infusion and in 24 patients receiving placebo at 2 weeks and 1 year after surgery. Zoledronic acid prevented loss of bone mineral density at 1 year (+ 13.8% vs + 1.4%, P = .0065) and 2 years (+ 14.3% vs − 4.0%, P < .0001) in Gruen zone 1, at 1 year (− 8.4% vs − 25.4%, P < .0001) and 2 years (− 9.6% vs − 27.3%, P < .0001) in Gruen zone 7, at 6 weeks, 6 months, and 1 or 2 years in Gruen zones 4 and 6. For all Gruen zones, prevention of BMD loss by ZOL was significant at 6 weeks, 6 months, 1 year (+ 0.80% vs − 6.03%, P < .0001) and 2 years (-0.16% vs − 7.13%, P < .0001).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Arthroplasty - Volume 28, Issue 4, April 2013, Pages 671–675
نویسندگان
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