کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4099922 | 1268664 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biomechanical evaluation of kyphoplasty with calcium phosphate cement in a 2-functional spinal unit vertebral compression fracture model Biomechanical evaluation of kyphoplasty with calcium phosphate cement in a 2-functional spinal unit vertebral compression fracture model](/preview/png/4099922.png)
Background contextKyphoplasty is used to treat vertebral compression fractures (VCFs) by inflating a balloon within the vertebral body (VB) to create a void, thereby reducing the fracture, and then depositing polymethylmethacrylate (PMMA) into that void to augment the VB. Calcium phosphate (CaP) may be preferable to PMMA because it is resorbable and nontoxic, although there are concerns about its compressive strength during the setting process.PurposeTo evaluate the ability of a particular self-setting CaP cement to restore the structural integrity of a VCF in a 2-functional spinal unit (2FSU) cadaver model under physiologically relevant loading.Study design/settingRepeated-measures compressive testing on a cadaver thoracolumbar 2FSU VCF model.MethodsTen 2FSU thoracolumbar specimens were tested to evaluate structural integrity under compressive loading during initial anterior VCF creation (in the central VB), after fracture, and after kyphoplasty treatment. Bipedicular kyphoplasty treatment was performed in a 37°C chamber to reduce the fracture and create a void, which was filled with CaP (n=5) or PMMA (n=5) and allowed to cure for at least 15 minutes. Using fluoroscopic imaging, the sagittal area of the VB (SAVB), the minimum central VB height (MCVBH), and the wedge angle were measured on the central VB for each condition at a 1,000-N compressive load. A repeated-measures linear model was used to determine if the differences in these parameters among the various experimental conditions were statistically significant (p< .05).ResultsCompared with the fractured condition, there was a significant improvement in the SAVB, MCVBH, and wedge angle under a physiologically relevant 1,000-N compressive load applied after kyphoplasty. There was no statistically significant difference between treatment with CaP or PMMA.ConclusionsThe structural properties of CaP-augmented VBs are similar to those of PMMA-augmented VBs. Our study indicated that, after at least 15 minutes of setting, a fractured 2FSU specimen treated with kyphoplasty with PMMA or CaP could withstand physiologically relevant loading.
Journal: The Spine Journal - Volume 8, Issue 5, September–October 2008, Pages 770–777