کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4131463 1271234 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular diagnosis in breast cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Molecular diagnosis in breast cancer
چکیده انگلیسی

Breast cancer is a complex and heterogeneous disease, encompassing a plethora of different entities with distinct biological features and clinical behaviour. The advent of high throughput molecular methods has allowed a systematic characterization of the molecular subtypes of breast cancer, the identification of novel therapeutic targets, and prognostic/predictive ‘gene signatures’. These methods are having a profound effect on the understanding of breast cancer, but their use in clinical practice is still rather limited.In this review, we discuss the main contribution of molecular methods for breast cancer research and how this information is changing the diagnosis and management of breast cancer. We also address novel developments in the diagnosis and management of HER2-positive breast carcinomas and familial breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 14, Issue 5, May 2008, Pages 202–213
نویسندگان
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