Increased magnesium intake prevents hyperlipidemia and insulin resistance and reduces lipid peroxidation in fructose-fed rats

Studies have suggested that type 2 diabetes mellitus is associated with abnormal lipid metabolism, oxidative stress and insulin resistance. Increased magnesium intake may improve dyslipidemia, oxidative stress and insulin insensitivity in type 2 diabetes. Therefore, the present study investigated the influence of increasing dietary magnesium from 0.1% to 1.0% for 4 weeks on plasma lipids, lipid peroxidation, l-ascorbic acid and insulin sensitivity in male Wistar rats fed a high-fructose diet. The rats were divided into control (CR), fructose-fed (FRU-fed) and fructose-fed supplemented with magnesium (FRU-Mg-fed) groups (n = 8 per group). Homeostasis model assessment for insulin resistance (HOMA-IR) and plasma thiobarbituric acid-reactive substances (TBARS) were used as indices of insulin sensitivity and lipid peroxidation, respectively. When compared with controls, the FRU-fed group had significantly higher values of HOMA-IR, fasting plasma glucose, insulin, triglyceride, total cholesterol/HDL-cholesterol ratio (atherogenic index), and TBARS. Their values in FRU-Mg-fed group were close to those of the controls. FRU-Mg-fed group had also significantly higher plasma magnesium and l-ascorbic acid levels, but significantly lower LDL-cholesterol levels than those in control and Fru-fed groups. Conclusion: increased magnesium intake improved insulin sensitivity, hyperglycemia, hyperlipidemia and reduced lipid peroxidation in fructose-fed rats.