کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4168642 1607549 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Fish Oil Supplementation on Fatty Acid Status, Coordination, and Fine Motor Skills in Children with Phenylketonuria
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Effect of Fish Oil Supplementation on Fatty Acid Status, Coordination, and Fine Motor Skills in Children with Phenylketonuria
چکیده انگلیسی

ObjectiveTo investigate effects of long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) on motor skills in patients with phenylketonuria (PKU).Study designThirty-six patients with PKU (1-11 years of age, good metabolic control: plasma phenylalanine ≤360 μmol/L for ≥6 months). We determined plasma phospholipid fatty acids, and in patients >4 years of age (N = 24) the motometric Rostock-Oseretzky Scale (ROS), before and after supplementation with fish oil for 3 months (15 mg docosahexaenoic acid [DHA]/kg body weight daily). ROS was also assessd in 22 age-matched controls.ResultsPatients had low n-3 LC-PUFA in plasma phospholipids (DHA, 2.37 ± 0.10%; eicosapentaenoic acid [EPA], 0.4 ± 0.03%) and poorer ROS performance than controls (motor development index [MQ] 107 ± 3 vs 117 ± 3, P = .010). Supplementation increased phospholipid n-3 LC-PUFA (DHA 7.05 ± 0.24%; EPA 3.31 ± 0.19%; P < .001), decreased n-6 LC-PUFA (arachidonic acid, 9.26 ± 0.23% vs 6.76 ± 0.16%; P < .001) and improved ROS (MQ 115 ± 3.54, P = .011, paired t test). ROS was unchanged in 11 retested controls (MQ 115 ± 5.16, P = NS, paired t test multivariate analysis of variance [MANOVA] for time by group, P = .027). Patients tolerated fish oil well. Plasma phenylalanine remained unchanged.ConclusionIn patients with PKU, fish oil supplementation enhances n-3 LC-PUFA levels and improves motor skills.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 150, Issue 5, May 2007, Pages 479–484
نویسندگان
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