کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4169194 1607556 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary lipids and intestinal inflammatory disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Dietary lipids and intestinal inflammatory disease
چکیده انگلیسی

Inflammatory bowel diseases (IBD) are chronic recurrent intestinal inflammatory disorders that are occurring with an increasing prevalence among Westernized nations and younger age groups. IBD is multifactorial, involving genetic, environmental, and immunologic factors that combine to promote an exaggerated immune response associated with failure of appropriate regulatory feedback mechanisms that terminate the response to stimuli. The increase in IBD has followed a similar pattern to the increase in dietary n-6 fatty acids and n-6/n-3 fatty acid ratio. Plausible mechanisms to suggest that high intakes of linoleic acid may contribute to IBD include inhibition of eicosapentaenoic acid and docosahexaenoic acid synthesis, increased synthesis and membrane incorporation of arachidonic acid with production of proinflammatory mediators, and increased oxidative stress in LA-rich membranes. High n-6 fatty acids in the neonatal milk diet result in increased colonic n-6 fatty acids and an exaggerated response to chemically induced colitis, whereas a milk diet low in n-6 and high in n-3 fatty acids increases colonic n-3 fatty acids and lowers colonic damage. High dietary n-6 fatty acids and n-6/n-3 fatty acid ratios may be important environmental modifiers that contribute to IBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 149, Issue 5, Supplement, November 2006, Pages S89–S96
نویسندگان
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