Pentoxifylline Attenuates Transforming Growth Factor-β1-Stimulated Collagen Deposition and Elastogenesis in Human Tunica Albuginea-Derived Fibroblasts Part 1: Impact on Extracellular Matrix

Both elastin and collagen are upregulated by TGF-β1 in TADF. This likely contributes to the PD phenotype. Pretreatment with PTX attenuates both collagen fiber deposition and elastogenesis in TADF exposed to TGF-β1; these effects suggest a useful role for PTX in the management of PD. Shindel AW, Lin G, Ning H, Banie L, Huang Y-C, Liu G, Lin C-S, and Lue TF. Pentoxifylline attenuates TGF-β1 stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts Part 1: Impact on extracellular matrix.