کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4278304 1611492 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat
ترجمه فارسی عنوان
دیکلوفناک باعث نشت آناستوموز در کولون پروگزیمال می شود، اما در کولون دیستال موش صحرایی نیست
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundNonsteroidal anti-inflammatory drugs have been associated with anastomotic leakage. It was studied if diclofenac affects anastomoses differently depending on the location in the gut.MethodsNinety-five rats were randomized to 6 groups with an anastomosis in either ileum (IL), proximal colon (PC), or distal colon (DC). Groups IL+ (n = 10), PC+ (n = 30), and DC+ (n = 10) received diclofenac (3 mg/kg/day) from day 0 until sacrifice on day 3. Group PC− (n = 15) did not receive diclofenac. Groups PC1+ and PC2+ (n = 15 each) were given diclofenac from day 1 to 4 and from day 2 to 5.ResultsLeak rates were 10/10 in group IL+, 22/30 in PC+, 1/10 in DC+, and 1/15 in PC−. Delayed administration of diclofenac by 1 or 2 days (6/15, P = .05) resulted in reduced leakage rates. Mechanical strength results corresponded with leak rates.ConclusionsDiclofenac causes leakage of anastomoses in rat IL and PC, but not in the DC. This suggests a role for the ileal and proximal colonic content in diclofenac-induced leakage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 210, Issue 2, August 2015, Pages 382–388
نویسندگان
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