کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4279740 1611530 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence
چکیده انگلیسی

BackgroundThe greater omentum with its vascularization and blood flow has been considered as a location for islet transplantation; however, there is a need to provide a controlled and protected site for the islets within the omentum that would be applicable to donor islets and future stem cell technologies. Here we describe the use of a novel device implanted within the omentum with a subcutaneous delivery port that offers an environment for donor islets.MethodsA prototype cell pouch device was wrapped in the greater omentum and an islet implantation port was exposed subcutaneously in diabetic Lewis rats. After tissue growth throughout the device, islet isografts were implanted and long-term glucose control was evaluated.ResultsBy using this technique, 7 of 10 diabetic rat recipients showed long-term normal blood glucose levels after minimal islet dose transplants. Histologic assessment revealed collagen formation and vascularization within the device.ConclusionsThe implanted device assessed using this technique provides a safe and efficacious environment for the support of pancreatic islets contained within a removable device as a cell therapy in a highly vascularized setting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 203, Issue 6, June 2012, Pages 793–797
نویسندگان
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