کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4294712 1612309 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elastic Fiber Depletion in the Supporting Ligaments of the Gastroesophageal Junction: A Structural Basis for the Development of Hiatal Hernia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Elastic Fiber Depletion in the Supporting Ligaments of the Gastroesophageal Junction: A Structural Basis for the Development of Hiatal Hernia
چکیده انگلیسی

BackgroundThe position of the gastroesophageal junction is maintained by a complex of fibroelastic ligaments. The purpose of this study was to characterize and compare the histology of these ligaments in patients with gastroesophageal reflux disease (GERD) and hiatal hernia (HH) versus GERD alone, with emphasis on the elastin morphology.Study DesignThirteen patients were examined at the time of laparoscopic fundoplication for symptomatic GERD; nine had no significant HH and four had large diaphragmatic hernias (GERD/HH). Tissue biopsies were obtained from the gastrohepatic ligament (GHL, n = 5 and n = 3, GERD and GERD/HH, respectively), the phrenoesophageal ligament (n = 7 and n = 4, respectively), and the gastrophrenic ligament (n = 6 and n = 4, respectively). Sections of fixed tissue were stained with hematoxylin and eosin, Masson's trichrome, and resorcin-fuchsin for analysis of elastic fibers by light microscopy, and elastin area was quantified and expressed as a percentage of the imaged tissue.ResultsElastin and collagen fibers were prominent in all ligaments in patients with GERD alone. In patients with GERD/HH, there was fragmentation and distortion of elastin in the phrenoesophageal ligament and gastrohepatic ligament, and to a lesser degree, in the gastrophrenic ligament. Compared with patients with GERD alone, the presence of hiatal hernia was associated with a reduction in elastin area by more than 50% in the phrenoesophageal ligament ([mean ± SEM] 31.0% ± 3.3% versus 15.1% ± 1.3%, p < 0.01) and gastrohepatic ligament (26.9% ± 0.5% versus 12.5% ± 0.1%, p < 0.008). There was no decrease with respect to elastin in the gastrophrenic ligament.ConclusionsThe periesophageal ligaments in patients with GERD are characterized by prominent elastic fibers. In contrast, GERD/HH is associated with depletion of elastic fibers in two of three ligaments supporting the gastroesophageal junction. Elastic fiber depletion in the periesophageal ligaments thereby provides a structural basis for the development of HH. It remains unclear if this represents a primary (etiologic) alteration or if it is a secondary phenomenon.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Surgeons - Volume 207, Issue 2, August 2008, Pages 191–196
نویسندگان
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