کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4311525 | 1612783 | 2009 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Stressed Host Response to Infection: The Disruptive Signals and Rhythms of Systemic Inflammation
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
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چکیده انگلیسی
The cognate signals from sterile or pathogen-induced sources converge on the same recognition or response pathways. In the surgical patient, a systemic response to infection most often occurs in the context of ongoing inflammatory stress. Such an inflammatory response is modulated initially by the magnitude of injury and by patient-specific (endogenous) factors, such as confounding illness, age, and genetic variation. Over an extended period of stress, treatmentrelated (exogenous) factors add unpredictability to host responses to subsequent challenges, such as acquired infection. The host response is discussed in the context of how existing sterile stressors may modify the response to acquired infection in surgical patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Clinics of North America - Volume 89, Issue 2, April 2009, Pages 311–326
Journal: Surgical Clinics of North America - Volume 89, Issue 2, April 2009, Pages 311–326
نویسندگان
Stephen F. Lowry,