کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4324572 | 1613912 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of duration and timing of prenatal stress on hippocampal myelination and synaptophysin expression
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کلمات کلیدی
PNDMWMPrenatal stress - استرس دوران بارداریTem - این استgestational day - روز بارداریpostnatal day - روز پس از زایمانSynaptophysin - سیناپتوفیزینMorris water maze - ماز آب آب موریسDuration - مدت زمانMyelination - میلیناسیونTransmission electron microscopy - میکروسکوپ الکترونی عبوریHippocampus - هیپوکامپ female control - کنترل زن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of duration and timing of prenatal stress on hippocampal myelination and synaptophysin expression Effects of duration and timing of prenatal stress on hippocampal myelination and synaptophysin expression](/preview/png/4324572.png)
چکیده انگلیسی
The relationship between prenatal stress (PS) exposure and neurodevelopmental deficits remains inconclusive, especially when assessing the role of PS duration and timing and sex-dependent effects. This study explored a sex-specific association between the duration and timing of exposure and the outcomes of PS-induced neurotoxicity in hippocampal microstructure, synaptophysin expression, and neurobehavioral performance in rats. Pregnant rats were randomly assigned to control, PS-ML (exposed to prenatal restraint stress in the mid-to-late period of pregnancy), or PS-L (exposed in the late period of pregnancy) groups, and offspring in each group were divided into two subgroups by sex. Surface-righting reflex test, cliff avoidance test and Morris water maze test showed that neurodevelopmental levels were reduced in PS-treated pups but without significant sex differences. On postnatal day 22, hippocampal microstructure was examined by electron microscopy, and the expression of hippocampal synaptophysin was assessed by western blot. Abnormal ultrastructural appearance of hippocampal neurons and myelin sheaths, more degenerating neurons and higher G-ratios were found in young PS-ML and PS-L rats as well as reduced expression of hippocampal synaptophysin, although PS-ML pups were more greatly affected than PS-L, with males showing slightly greater impairments than females. These findings suggest that hippocampal hypo-myelination and decreased synaptophysin expression in neurodevelopment may be a duration and time-dependent effect of prenatal stress exposure, modified slightly by sex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1527, 21 August 2013, Pages 57-66
Journal: Brain Research - Volume 1527, 21 August 2013, Pages 57-66
نویسندگان
Jian Xu, Bo Yang, Chonghuai Yan, Howard Hu, Shizhong Cai, Junxia Liu, Meiqin Wu, Fengxiu Ouyang, Xiaoming Shen,