Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation

► NADPH oxidase activation induces oxidative damage after traumatic brain injury (TBI). ► NADPH oxidase activation induces BBB disruption and microglial activation after TBI. ► NADPH oxidase activation induces neuron death after TBI. ► NADPH oxidase inhibition prevents TBI-induced oxidative injury in rats. ► High dose apocynin pre-treatment prevents TBI-induced neuronal death in rats.