Decreased levels of nuclear glucocorticoid receptor protein in the hippocampus of aged Long-Evans rats with cognitive impairment

► Aged male Long-Evans rats with cognitive impairment. ► Glucocorticoid receptor (GR) protein and GRE binding activity in the hippocampus. ► Decreased GR protein in the nucleus but not in the cytosol in the hippocampus with memory impairment. ► GRE binding activity was decreased in the hippocampus with memory impairment. ► Impaired GR signaling in aged rats with cognitive impairment.