کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4326821 | 1614095 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-related changes in the central auditory system: Comparison of d-galactose-induced aging rats and naturally aging rats
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کلمات کلیدی
MDAPresbycusisIPLMLRABRD-galactose - D-گالاکتوزMitochondrial DNA - DNA میتوکندریاTem - این استTUNEL - تونلcommon deletion - حذف معمولApoptosis - خزان یاختهایd-gal - د-گالmtDNA - دیانای میتوکندریاییAging - سالخوردگیAuditory Cortex - قشر شنواییmalondialdehyde - مالون دی آلدهیدTransmission electron microscope - میکروسکوپ الکترونی انتقالCochlear Nucleus - هسته کچلرMiddle latency response - پاسخ تاخیری درسطحauditory brainstem response - پاسخ شنوایی مغزInferior colliculus - کولیکولوس پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
One of the most common complaints among aging individuals is difficulty in understanding speech in a compromised listening environment, such as when background noise is present. Age-related hearing loss (presbycusis) is associated with both peripheral and central neural processing deficits, as it occurs even in those with only a mild peripheral hearing impairment. The current study was designed to investigate potential causative mechanisms of this impairment by using a rat model in which presbycusis is inducible by administration of d-galactose (d-gal). One group of these rats was injected subcutaneously with 150Â mg d-gal daily for 8Â weeks, while control animals received vehicle only. These groups were compared to naturally aged rats (24Â months) that had received no other treatment. Central auditory function of the three groups was evaluated by measuring the auditory brainstem response (ABR) and middle latency response (MLR). A TaqMan real time PCR assay was used to quantify a 4834-bp deletion in the mitochondrial DNA (mtDNA) of the auditory cortex (AC), inferior colliculus (IC) and cochlear nucleus (CN). We assessed changes in lipid peroxidation levels and apoptosis rates, and examined pathological changes corresponding to d-gal-induced aging and natural aging. Both groups of aged rats exhibited delayed ABR latencies (III, IV, V), MLR Pa latency, and I-IV interpeak latency. Moreover, increased mtDNA 4834Â bp deletion rates, lipid peroxidation levels, rates of neuronal apoptosis and neurodegenerative changes in the AC, IC and CN were similar among the d-gal induced and NA rats. However, the threshold of ABR in the d-gal group showed no significant change from the control group. These observations suggest that age-related central auditory dysfunction and its corresponding pathological changes are present in both naturally aging rats and the d-gal mimetic aging model. Oxidative stress, large-scale mtDNA 4834Â bp deletion, and apoptosis are likely to be involved in the progressive weakening of the central auditory system associated with the aging process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1344, 16 July 2010, Pages 43-53
Journal: Brain Research - Volume 1344, 16 July 2010, Pages 43-53
نویسندگان
Bei Chen, Yi Zhong, Wei Peng, Yu Sun, Wei-Jia Kong,