کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332768 | 1292910 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not l-NAME, on the in vitro neonatal rat spinal cord preparation
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کلمات کلیدی
COXMSRIC50aCSFEPSP - epspil-NAME - L-NAMENω-nitro-l-arginine methyl ester - N-Nitro-L-Arginine Methyl Estercyclooxygenase - آنزیم سیکلواکسیژنازi.t. - آی تی.Arachidonic acid - اسید آراشیدونیکintrathecal - اینتراکتالconfidence intervals - فاصله اطمینانartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not l-NAME, on the in vitro neonatal rat spinal cord preparation Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not l-NAME, on the in vitro neonatal rat spinal cord preparation](/preview/png/4332768.png)
چکیده انگلیسی
Activation of spinal N-methyl-d-aspartate (NMDA) receptors and then the nitric oxide and the arachidonic acid pathways is important in pain transmission. This study assessed the effects of the NMDA receptor channel blocker ketamine, the nitric oxide synthase inhibitor l-NAME, and the cyclooxygenase inhibitor ketoprofen in nociceptive transmission using an in vitro neonatal rat spinal cord preparation. Supramaximal electrical stimulation of the dorsal root evoked the A-fibre- and C-fibre-mediated high intensity excitatory postsynaptic potential (EPSP) in the ipsilateral ventral root. Low intensity stimulation evoked the A-fibre-mediated monosynaptic compound action potential (MSR) superimposed on the low intensity EPSP. Both the low intensity EPSP and the high intensity EPSP contain NMDA-receptor-mediated components. Only ketamine and ketoprofen depressed the synaptic responses. Ketamine depressed all three spinal reflexes with IC50 values (with 95% CI) of 10.80 μM (5.97 to 19.54 μM) for the MSR, 8.29 μM (4.53 to 14.17 μM) for the low intensity EPSP, and 5.35 μM (3.05 to 9.40 μM) for the high intensity EPSP. Ketoprofen depressed the low intensity EPSP and the high intensity EPSP only; IC50 values (with 95% CI) were 354.5 μM (217.5 to 576.8 μM) and 302.7 μM (174.0 to 526.7 μM), respectively. Reflexes recovered after drug washout. These data demonstrated that ketamine and ketoprofen, but not l-NAME, depressed NMDA-mediated nociceptive transmission in spinal cord preparations from neonatal rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1094, Issue 1, 13 June 2006, Pages 57-64
Journal: Brain Research - Volume 1094, Issue 1, 13 June 2006, Pages 57-64
نویسندگان
I. Lizarraga, J.P. Chambers, C.B. Johnson,