کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4333116 | 1292921 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Blockade of presynaptic voltage-gated calcium channels in the medial prefrontal cortex of neonatal rats leads to post-pubertal alterations in locomotor behavior
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Amphetamine - آمفتامین هاSchizophrenia - اسکیزوفرنی یا شیزوفرنیLocomotion - حرکتSensitization - حساسیتDevelopment - رشدBehavior - رفتارpsychostimulant - روانشناسیprefrontal cortex - قشر prefrontalAnimal model - مدل حیوانیPrepulse Inhibition of Startle - مهار پیش از قاعدگی شروعActivity dependent - وابسته به فعالیتCalcium channel - کانال کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although the etiology of neurodevelopmental mental disorders remains obscure, converging lines of evidence using animal modeling suggest a critical role for activity-dependent neurodevelopmental processes during neonatal life. Here, we report the behavioral effects of a novel technique designed to induce targeted, transient disruption of activity-dependent processes in early development via reduction of calcium-mediated neurotransmitter release. We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal cortex infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (Ï-conotoxins MVIIA and MVIIC respectively; 6.8 and 45Â pmol infused respectively) in rat pups. In a test of amphetamine-induced behavioral sensitization, neonatal Ï-conotoxin MVIIA treatment significantly increased locomotion following repeated amphetamine injections (1.5Â mg/kg i.p.) and significantly decreased locomotion following repeated saline injections relative to animals treated neonatally with vehicle. However, there was no effect of conotoxin treatment on the long-term expression of amphetamine sensitization. Neonatal treatment with Ï-conotoxins had no effect on the other behaviors assayed, namely, acoustic startle response, prepulse inhibition of startle, novelty- and amphetamine-induced (1.5Â mg/kg i.p.) locomotion, and anxiety-like behavior in the elevated plus-maze. These data confirm that transient, region-specific disruption of synaptic transmission during early development can have long-term effects on behaviors relevant to neurodevelopmental mental disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1083, Issue 1, 14 April 2006, Pages 164-173
Journal: Brain Research - Volume 1083, Issue 1, 14 April 2006, Pages 164-173
نویسندگان
Clifford M. Cassidy, Rémi Quirion, Lalit K. Srivastava,