کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4333189 | 1292925 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague-Dawley rats
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کلمات کلیدی
potassium phosphate buffered salineAVPAMPHBSTMPFCPRLKPBSDEPCPFAIMOc-fos mRNACRFControl animalsSSCinfralimbic areaDTTLSVACTHMEAmedial amygdala - آمدیگدال medialAmphetamine - آمفتامین هاEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدStress - استرس یا فشار روانیinterleukin 1-β - اینترلوکین 1-βanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetriethanolamine - تری اتانولامینSMA - دبیرستانdiethylpyrocarbonate - دیاتیلپیر کربناتdithiothreitol - دیتیوتریتولSaline Sodium Citrate - سدیم سدیم سدیمRat strain - فشار رودهmedial prefrontal cortex - قشر غده پروسترولlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالPrelimbic area - منطقه پیش دبستانیmedial preoptic area - منطقه پیشوپتیک مدیاSprague–Dawley rat - موش Sprague-DawleySprague–Dawley rats - موش Sprague-DawleyLewis rats - موش لوئیسLewis rat - موش لوئیسHPA - میلی بار یا هکتوپاسکالbed nucleus of stria terminalis - هسته تخت ترمینال striaparaventricular nucleus - هسته پروژسترویکadrenocorticotropic hormone - هورمون adrenocorticotropicHybridization in situ - هیبریداسیون در محلarginine vasopressin - وازوپرسین آرژینینparaformaldehyde - پارافرمالدهیدTEA - چایcorticotrophin-releasing factor - کورتیکوتروپین آزاد کننده فاکتور
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In order to study the contribution of genetic factors to the pattern of stress-induced brain activation, we studied the expression of c-fos mRNA, a marker of neuronal activity, in male Sprague-Dawley and Lewis strains, the latter being known to have a deficient responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis. Immobilization (IMO) alone or combined with the immersion into water at 21 °C was applied for 15 or 60 min. The expression of c-fos mRNA was quantified by in situ hybridization in those brain areas that represent important parts of neuronal circuits activated by stress: medial prefrontal cortex, medial amygdala, lateral septum ventral part, paraventricular nucleus of the hypothalamus and locus coeruleus. While in controls, c-fos mRNA was not detectable in tested brain areas, both types of stressors induced a strong expression of this immediate early gene. There were only small differences in c-fos mRNA expression related to the type of stressor or the length of exposure to them. However, there were remarkable differences in the expression between the two rat strains. When compared to Sprague-Dawley rats, Lewis rats showed a reduced c-fos mRNA expression after both stressors in most brain areas, which may be related to the reduced responsiveness of HPA axis and also with other abnormal responses in this strain. However, this hyporesponsiveness was not observed in all brain areas studied, suggesting that there is not a generalized defective c-fos response to stress in Lewis rats and that some responses to stress may be normal in this strain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1077, Issue 1, 10 March 2006, Pages 7-15
Journal: Brain Research - Volume 1077, Issue 1, 10 March 2006, Pages 7-15
نویسندگان
Lenka TrneÄková, Antonio Armario, Sixtus Hynie, Pavel Å Ãda, VÄra Klenerová,