کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4333242 1292926 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term memory for aversive training is impaired in Idua−/− mice, a genetic model of mucopolysaccharidosis type I
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Long-term memory for aversive training is impaired in Idua−/− mice, a genetic model of mucopolysaccharidosis type I
چکیده انگلیسی

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease that leads to neurodegeneration and neurological deficits, among other pathological and clinical consequences. The aim of the present study was to evaluate neurobehavioral parameters in a genetic mouse model of mucopolysaccharidosis type I (MPS I). During exploration of an open field, adult MPS I (Idua−/−) mice showed normal locomotion and anxiety but reduced number of rearings. Idua−/− mice performed normally in a novel object recognition memory task and showed normal short-term retention of inhibitory avoidance training. By contrast, long-term retention of inhibitory avoidance was impaired in Idua−/− mice. The deficit in inhibitory avoidance memory could not be attributed to reduced footshock reactivity. The results indicate that Idua−/− mice present deficits in long-term memory for aversive training and reduced exploratory behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1076, Issue 1, 3 March 2006, Pages 225–230
نویسندگان
, , , , , , ,