کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4333955 1294760 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal formation: Shedding light on the influence of sex and stress on the brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Hippocampal formation: Shedding light on the influence of sex and stress on the brain
چکیده انگلیسی

The hippocampus is a malleable brain region that responds to external agents such as hormones and stressors. Investigations that began in our laboratories with the Golgi technique and an appreciation of hippocampal neuroanatomy at the light and electron microscopic levels have led us down a path that has uncovered unexpected structural plasticity in the adult brain along with unanticipated cellular and molecular mechanisms of this plasticity and of hormone mediation of these effects. This chapter reviews the history of discoveries in our two laboratories involving the actions of estradiol and stress hormones on neuronal structure and function and then discusses the insight to hormone–brain interactions that this has engendered. These discoveries have led us to a new view of brain structural plasticity and the role and mechanism of steroid hormone action involving both genomic and non-genomic pathways. This new view is consistent with the predictions of Cajal in his book “The Structure of Ammon’s horn”, 1892.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 55, Issue 2, October 2007, Pages 343–355
نویسندگان
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