کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4337925 | 1614832 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perinatal undernutrition attenuates field excitatory postsynaptic potentials and influences dendritic spine density and morphology in hippocampus of male rat offspring
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کلمات کلیدی
fEPSPPD0I–OIUGRPD1HFSPTPBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Golgi impregnation - آغشته سازی گلژیhigh-frequency stimulation - تحریک فرکانس بالاanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancelong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP postnatal day 0 - روز بعد از تولد 0postnatal day 1 - روز بعد از زایمان 1postnatal day - روز پس از زایمانBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزintrauterine growth restriction - محدودیت رشد داخل رحمیpyramidal neuron - نورون هرمیHippocampus - هیپوکامپ input–output - ورودی خروجیPost-tetanic potentiation - پتانسیل پست تکتانیکexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیرMaternal undernutrition - کمبود تغذیه مادرانLearning and memory - یادگیری و حافظه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Perinatal undernutrition affects the hippocampus, a brain region crucial for learning and memory. However, far less is known about the changes of dendritic spine density and morphology related to hippocampal synaptic plasticity. As dendritic spines are dynamic structures essential for synaptic plasticity and serve as the primary post-synaptic location of the excitatory neurotransmission that underlies learning and memory, the aim of the present study was to investigate whether the perinatal undernutrition affected hippocampal synaptic plasticity accompanied by the change of dendritic spines in anesthetized rats. An input-output curve was first determined using the measurements of field excitatory postsynaptic potential (fEPSP) slope in response to a series of stimulation intensities. Long-term potentiation (LTP) induced by high-frequency stimulation was recorded in the Schaffer collateral-CA1 pathway. Post-tetanic potentiation derived from the fEPSP slope was also measured immediately after LTP induction. Quantitative data of dendritic spines from hippocampal CA1 pyramidal cells were obtained using Golgi staining. The results showed that 50% perinatal food restriction (FR50) impaired the magnitude of LTP of the fEPSP slope in the Schaffer collateral-CA1 pathway. Additionally, FR50 reduced overall spine densities in both basal dendrites and apical dendrites of hippocampal CA1 pyramidal cells. Moreover, FR50 reduced type densities of thin and mushroom spines in apical dendrites, whereas a reduction in the type of mushroom spines was only observed in the basal dendrites of hippocampal CA1 pyramidal cells. These findings suggested that perinatal undernutrition decreased excitatory synaptic input and further affected the processing of information in a given network by selectively reducing the number of special dendritic spines. Thus, these changes in the density and the types of dendritic spines in CA1 pyramidal neurons may partly explain the impaired hippocampal synaptic plasticity as well as learning and memory disturbances commonly observed during undernourished rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 244, 6 August 2013, Pages 31-41
Journal: Neuroscience - Volume 244, 6 August 2013, Pages 31-41
نویسندگان
Zhang Y., Wei J., Yang Z.,