کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4337998 | 1614833 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3
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کلمات کلیدی
RMSGastrocnemiusSCA3SCA6APAsEMG - الکترومیوگرافیelectromyographic - الکترومیوگرافیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceAnticipatory postural adjustments - تنظیمات پیش بینی پیش بینی شدهBiceps femoris - دوشادوش فمورسpostnatal day - روز پس از زایمانroot mean square - میانگین مربع ریشهSpinocerebellar Ataxia Type 3 - نوع Ataxia نوع 3 SpinocerebellarSpinocerebellar ataxia type 6 - نوع آتاکسی اسپینوسئر سلول 6hemagglutinin - هماگلوتینین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3 Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3](/preview/png/4337998.png)
چکیده انگلیسی
During voluntary limb movements, humans exert anticipatory postural adjustments (APAs) to prevent any upcoming equilibrium disturbance that might be provoked by limb movements. Dysfunction in generation or control of APAs is associated with postural deficits in some human patients with cerebellar damage. To examine the role of the cerebellum in APAs, we investigated a conditional transgenic mouse of spinocerebellar ataxia type 3 (SCA3Tg) that has defective cerebellar Purkinje cells. Kinematic analyses and monitoring of electromyographic activities during quadrupedal standing showed that SCA3Tg mice exhibited greater hindlimb instability than wild-type (WT) mice. This instability increased during a reaching task that required postural adjustments associated with voluntary neck movements. Normally, the activities of the hindlimb muscles are synchronized with those in the neck that are the agonists for movement of the head in this reaching task; however, in SCA3Tg mice, activities in the hindlimbs were markedly delayed compared to the neck. These observations cannot simply be explained as a secondary outcome of the muscle atrophy that occurs in SCA3Tg mice. In WT mice with muscle atrophy induced by immobilization of the hindlimbs, we did not find impairment of APAs. These findings suggest that the deficits in APAs during the reaching task in SCA3Tg mice were not due to muscle atrophy in the hindlimbs, but were mainly caused by cerebellar degeneration. Therefore, we conclude that the cerebellum is critically involved in APAs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 243, 23 July 2013, Pages 126-135
Journal: Neuroscience - Volume 243, 23 July 2013, Pages 126-135
نویسندگان
H. Yamaura, H. Hirai, D. Yanagihara,