کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338101 1614844 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Corticosteroids limit microglial activation occurring during acute stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Corticosteroids limit microglial activation occurring during acute stress
چکیده انگلیسی

Our previous studies demonstrated that exposure of animals to acute stress immediately induced morphological microglial activation in the brain. Here we investigated the effects of adrenal corticoids on microglial activation following acute stress. We compared microglial activation in vivo in adrenalectomized (ADX), Sham-operated (SHM), and adrenalectomy plus corticosterone (CORT) administered rats exposed to a 2-h period of acute water restraint stress. We found that: (1) acute stress induced microglial activation in SHM rats; (2) acute stress robustly enhanced microglial activation in ADX rats; (3) CORT treatment significantly reduced the effects of adrenalectomy. Thus, while acute stress has the ability to activate microglia, the magnitude of activation is negatively regulated by CORT. Glucocorticoids may serve as an important endogenous suppressive signal limiting neuroinflammation that might otherwise occur during stress.


► The present study investigated the effects of corticosteroids on microglia in the rat brain following acute stress.
► Acute stress induced microglial activation in Sham-operated rats.
► Acute stress in adrenalectomized rats robustly enhanced microglial activation.
► Corticosterone treatment in adrenalectomized rats significantly reduced the effects of adrenalectomy.
► Corticosteroids may provide suppressive signals for the microglial activation in the brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 232, 1 March 2013, Pages 13–20
نویسندگان
, , , , , ,