Functional interactions between the paraventricular hypothalamic nucleus and raphe magnus. A comparative study of an integrated homeostatic analgesic mechanism

▶PVN or RMg electric stimulation suppressed noxious activation in spinal cord cells. ▶PVN and RMg simultaneous stimulation produced a biggest suppressor effect. ▶RMg lesion did not suppress the PVN effect. ▶PVN-RMg pathway participates in the endogenous analgesic mechanisms. ▶PVN and RMg are part of multiple structures participating in pain and analgesia.