کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339468 | 1295755 | 2010 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Water transport between CNS compartments: contributions of aquaporins and cotransporters
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کلمات کلیدی
MCTAquaporinsNa+/K+/2Cl− cotransporterAQP4EAATcotransportersGATKCCNKCCaquaporin 4 - آکوپورین 4Cell swelling - تورم سلولیWater transport - حمل و نقل آبGlutamate transporter - حمل و نقل گلوتاماتGABA transporter - حمل کننده GABAglial cells - سلول های گلیالCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیmonocarboxylate transporter - مونوکربوکسیلاک حمل کنندهChoroid plexus - پیوند کوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid. This water flux is tightly regulated but may be disturbed under pathological conditions that lead to brain edema formation or hydrocephalus. The molecular pathways by which water molecules cross the cell membranes of the brain are not well-understood, although the discovery of aquaporin 4 (AQP4) in the brain improved our understanding of some of these transport processes, particularly under pathological conditions. In the present review we introduce another family of transport proteins as water transporters, namely the cotransporters and the glucose uniport GLUT1. In direct contrast to the aquaporins, these proteins have an inherent ability to transport water against an osmotic gradient. Some of them may also function as water pores in analogy to the aquaporins. The putative role of cotransport proteins and uniports for the water flux into the glial cells, through the choroid plexus and across the endothelial cells of the blood-brain-barrier will be discussed and compared to the contribution of the aquaporins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 168, Issue 4, 28 July 2010, Pages 941-956
Journal: Neuroscience - Volume 168, Issue 4, 28 July 2010, Pages 941-956
نویسندگان
N. MacAulay, T. Zeuthen,