کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339612 | 1295762 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synapse-glia interactions are governed by synaptic and intrinsic glial properties
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کلمات کلیدی
HEPESEPPSPSCsLALEDLtetraethylammonium chlorideNMJPerisynaptic Schwann cellsPTPTPENACh - آهNeuromuscular junction - اتصال عصبی عضلانیAcetylcholine - استیل کولینSol - سلperipheral nervous system - سیستم عصبی پیرامونیExtensor digitorum longus muscle - عضلات بازکننده انگشتان لونگوسSoleus muscle - عضله SoleusSynaptic strength - قدرت سیناپتیسMembrane potential - پتانسیل غشاء Post-tetanic potentiation - پتانسیل پست تکتانیکSynaptic plasticity - پلاستیسیته سیناپسیTEA - چایPNS - کارمندان دولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is believed that glial cell activation and their interactions with synapses are predominantly dependent upon the characteristics of synaptic activity and the level of transmitter release. Because synaptic properties vary from one type of synapse to another, synapse-glia interactions should differ accordingly. The goal of this work was to examine how glial cell activation is dependent upon the properties of their respective synapses as well as the level of synaptic activity. We contrasted Ca2+ responses of perisynaptic Schwann cells (PSCs) at neuromuscular junctions (NMJs) with different synaptic properties; the slow-twitch soleus (SOL) and the fast-twitch levator auris longus (LAL) muscles. Amplitude of PSC Ca2+ responses elicited by repeated motor nerve stimulation at 40, 50 and 100 Hz were larger and their kinetics faster at LAL NMJs and this, at all frequencies examined. In addition, a greater number of PSCs per NMJ was activated by sustained synaptic transmission at NMJs of LAL in comparison to SOL. Differences in PSC activation could not be explained solely by differences in levels of transmitter release but also by intrinsic PSC properties since increasing transmitter release with tetraethylammonium chloride (TEA) did not increase their responsiveness. As a whole, these results indicate that PSC responsiveness at NMJs of slow- and fast-twitch muscles differ not only according to the level of activity of their synaptic partner but also in accordance with inherent glial properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 167, Issue 3, 19 May 2010, Pages 621-632
Journal: Neuroscience - Volume 167, Issue 3, 19 May 2010, Pages 621-632
نویسندگان
I. Rousse, A. St.-Amour, H. Darabid, R. Robitaille,