کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340525 | 1295799 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus
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کلمات کلیدی
PBSChemoreflexPAAFos-immunoreactivityPAPPaVRVLMNTSrostral ventrolateral medulla - آرام آرامoxytocin - اکسیتوسینArterial chemoreceptors - شیمی درمانی شریانیHeart rate - ضربان قلبpulsatile arterial pressure - فشار خون شریانmean arterial pressure - فشار متوسط شریانیSympathetic activity - فعالیت سمپاییFos-ir - فوزیPVN - مالیات بر ارزش افزودهPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmap - نقشهnucleus tractus solitarius - هسته دستگاه انفرادیparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسparaventricular nucleus - هسته پروژسترویکvasopressin - وازوپرسینFos protein - پروتئین FOSPaPo - پوپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus](/preview/png/4340525.png)
چکیده انگلیسی
Despite the well-established sympathoexcitation evoked by chemoreflex activation, the specific sub-regions of the CNS underlying such sympathetic responses remain to be fully characterized. In the present study we examined the effects of intermittent chemoreflex activation in awake rats on Fos-immunoreactivity (Fos-ir) in various subnuclei of the paraventricular nucleus of the hypothalamus (PVN), as well as in identified neurosecretory preautonomic PVN neurons. In response to intermittent chemoreflex activation, a significant increase in the number of Fos-ir cells was found in autonomic-related PVN subnuclei, including the posterior parvocellular, ventromedial parvocellular and dorsal-cap, but not in the neurosecretory magnocellular-containing lateral magnocellular subnucleus. No changes in Fos-ir following chemoreflex activation were observed in the anterior PVN subnucleus. Experiments combining Fos immunohistochemistry and neuronal tract tracing techniques showed a significant increase in Fos-ir in rostral ventrolateral medulla (RVLM)-projecting (PVN-RVLM), but not in nucleus of solitarii tract (NTS)-projecting PVN neurons. In summary, our results support the involvement of the PVN in the central neuronal circuitry activated in response to chemoreflex activation, and indicate that PVN-RVLM neurons constitute a neuronal substrate contributing to the sympathoexcitatory component of the chemoreflex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 157, Issue 2, 19 November 2008, Pages 463-472
Journal: Neuroscience - Volume 157, Issue 2, 19 November 2008, Pages 463-472
نویسندگان
J.C. Cruz, L.G.H. Bonagamba, B.H. Machado, V.C. Biancardi, J.E. Stern,