کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341922 | 1295850 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tyrosine kinase receptor immunoreactivity in trigeminal mesencephalic and motor neurons following transection of masseteric nerve of the rat
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کلمات کلیدی
PBSMe5NGSMo5NGFMNTABCFluorogoldBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز axotomy - اگزوتیومImmunohistochemistry - ایمونوهیستوشیمیTrk - تراکTexas red - تگزاس قرمزTyrosine kinase - تیروزین کینازretrograde tracing - ردیابی عقب ماندهnormal goat serum - سرم طبیعی بزnerve growth factor - فاکتور رشد عصبBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریNeurotrophin - نوروتروفینTrigeminal nucleus - هسته سه هسته ایmotor trigeminal nucleus - هسته سه هسته ای موتورTrigeminal mesencephalic nucleus - هسته مزانسفالی تیژمینالavidin–biotin complex - پیچیده avidin-بیوتینTyrosine kinase receptor - گیرنده تیروزین کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tyrosine kinase receptor immunoreactivity in trigeminal mesencephalic and motor neurons following transection of masseteric nerve of the rat Tyrosine kinase receptor immunoreactivity in trigeminal mesencephalic and motor neurons following transection of masseteric nerve of the rat](/preview/png/4341922.png)
چکیده انگلیسی
Neurotrophins are known to promote survival after neural injury. To determine the relative importance of tyrosine kinase receptors on the survival of axotomized trigeminal nuclear neurons, we examined the temporal expression profile of tyrosine kinase A, tyrosine kinase B and tyrosine kinase C receptors in the mesencephalic trigeminal nucleus and the motor trigeminal nucleus following transection of the masseteric nerve in rats. Axotomized neurons in these nuclei were retrogradely identified with FluoroGold. We found increase in tyrosine kinase A-immunoreactive mesencephalic trigeminal nucleus neurons in the second week after axotomy but no change in the number of tyrosine kinase A-immunoreactive motor trigeminal nucleus neurons. There was no change in the number of tyrosine kinase B-immunoreactive mesencephalic trigeminal nucleus neurons but the significant increase of tyrosine kinase B-immunoreactive motor trigeminal nucleus neurons throughout the period of observation (3 weeks) peaked at â¼1 week after axotomy. There was no alteration in the number of tyrosine kinase C-immunoreactive mesencephalic trigeminal nucleus neurons but significant increase in tyrosine kinase C-immunoreactive motor trigeminal nucleus neurons observable by 4 days post-axotomy was followed by decline to levels lower than the control in 2 weeks. Temporal changes in the expression of individual tyrosine kinase receptors in mesencephalic trigeminal nucleus and motor trigeminal nucleus neurons following transection of the masseteric nerve suggest differential contribution of tyrosine kinase-specific neurotrophins to the survival of these neurons after axotomy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 3, 2006, Pages 921-930
Journal: Neuroscience - Volume 139, Issue 3, 2006, Pages 921-930
نویسندگان
F.X. Zhang, C.H. Lai, J.L. Li, D.K.Y. Shum, Y.S. Chan,