کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341988 | 1295852 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Attenuation of heart rate control and neural degeneration in nucleus ambiguus following chronic intermittent hypoxia in young adult Fischer 344 rats
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کلمات کلیدی
VRGDMNXΔHRNTSRVLRVLMParasympatheticCVLMCIHl-Glu - l-glurostral ventrolateral medulla - آرام آرامobstructive sleep apnea - آپنه خواب انسدادیl-glutamate - ال گلوتاماتOsa - بخشbaroreflex - رفلکس بارورسپتورHeart rate - ضربان قلبArterial blood pressure - فشار خون شریانیmean arterial pressure - فشار متوسط شریانیphenylephrine - فنیل آفرینHeart - قلب caudal ventrolateral medulla - مدولال ventrolateral کادالmap - نقشهsodium nitroprusside - نیتروپروساید سدیمnucleus ambiguus - هسته ابهامnucleus of the solitary tract - هسته دستگاه انفرادیdorsal motor nucleus of the vagus - هسته موتور پشتی وحشیroom air - هوا اتاقintermittent hypoxia - هیپوکسی متناوبchronic intermittent hypoxia - هیپوکسی متناوب مزمنSNP - چندریختی تک-نوکلئوتیدCardiac ganglia - گانگلیس قلبVentral respiratory group - گروه تنفسی انسدادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chronic intermittent hypoxia (CIH) attenuates baroreflex control of heart rate (HR). In this study, we assessed whether CIH exposure reduced nucleus ambiguus (NA) control of HR and induced neural degeneration in the NA. Fischer 344 (age: 3-4 months) rats were exposed to either room air (RA: normoxia) or intermittent hypoxia for 35-50 days. At the end of these exposures, animals were anesthetized with pentobarbital. HR responses to arterial blood pressure (AP) changes induced by phenylephrine (PE) and sodium nitroprusside (SNP) were measured. In another set of rats, HR and AP responses to l-glutamate (l-Glu) microinjections (10 mM, 20 nl) into the left NA and electrical stimulation of the left cervical vagus nerve at 1-30 Hz (0.5 mA, 1 ms) for 20 s were measured. Brainstem slices at the level of â800, â400, 0, +400, +800 μm relative to the obex were processed in additional rats using Nissl staining. The NA was identified by retrogradely labeling vagal motoneurons using the tracer tetramethylrhodamine dextran (TMR-D) which was injected into the ipsilateral nodose ganglion. We found that CIH significantly 1) reduced the baroreflex control of HR (slope RA: â1.2±0.2 bpm/mmHg; CIH â0.5±0.1 bpm/mmHg; P<0.05); 2) attenuated the HR responses to l-Glu injections into the NA [HR: â280±15 (RA) vs. â235±16 (CIH) beats/min; P<0.05]; 3) augmented the HR responses to electrical stimulation of the vagus (P<0.05); 4) induced a significant cellular loss in the NA region (P<0.05). Thus, CIH induces a cell loss in the NA region which may contribute to attenuation of baroreflex sensitivity and NA control of HR following CIH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 153, Issue 3, 15 May 2008, Pages 709-720
Journal: Neuroscience - Volume 153, Issue 3, 15 May 2008, Pages 709-720
نویسندگان
B. Yan, G.K. Soukhova-O'Hare, L. Li, Y. Lin, D. Gozal, W.B. Wead, R.D. Wurster, Z.J. Cheng,