کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342266 | 1295861 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereological estimation of Purkinje neuron number in C57BL/6 mice and its relation to associative learning
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کلمات کلیدی
SPLHSDS.D. - SD.Age-related hearing loss - افت شنوایی مرتبط با سنelectromyography - الکترومیوگرافیEMG - الکترومیوگرافیstandard deviation - انحراف معیارanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancehonestly significant difference - تفاوت صادقانه قابل توجه استDC, Direct current - جریان مستقیم، جریان پیوستهSound pressure level - سطح فشار صوتunconditioned stimulus - محرک بی قید و شرطconditioned stimulus - محرک شرطیCerebellum - مخچهconditioned response - پاسخ مشروطNormal aging - پیری طبیعیpersonal computer - کامپیوتر شخصیOptical fractionator - کسر کننده نوری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stereological estimation of Purkinje neuron number in C57BL/6 mice and its relation to associative learning Stereological estimation of Purkinje neuron number in C57BL/6 mice and its relation to associative learning](/preview/png/4342266.png)
چکیده انگلیسی
Cerebellar Purkinje neurons are among the most vulnerable neurons in the CNS. Impairment in Purkinje neurons has consequences for cerebellar cortical-dependent forms of behavior. The primary aim of this study was to evaluate Purkinje neuron number over the lifespan of C57BL/6 mice. Stereological estimates of the total number of Purkinje neurons in cerebellar cortex were made in 25 C57BL/6 mice aged 4, 8, 12, 18, and 24 months. Delay eyeblink classical conditioning to a white noise conditioned stimulus was also assessed for 10 daily sessions. Statistically significant age differences in Purkinje neuron number were observed beginning at 18 months. Delay eyeblink conditioning also showed significant age-related impairment, at least some of which resulted from age-related deficits in hearing. Eliminating the hearing-impaired 18- and 24-month-old mice from the analysis, the correlation between Purkinje neuron number and rate of conditioning was â0.435 (P=0.053) in 15 younger mice aged 4-12 months. Purkinje neurons are one of the few types of neurons showing significant age-associated loss. Results indicate that individual variation in Purkinje neuron number is related to eyeblink conditioning in young organisms suggesting that reserves of neuron numbers against which individuals draw are defined early in life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 141, Issue 1, 2006, Pages 233-243
Journal: Neuroscience - Volume 141, Issue 1, 2006, Pages 233-243
نویسندگان
D.S. Woodruff-Pak,