کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342660 | 1295881 | 2007 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease
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کلمات کلیدی
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine6-OHDAmedial terminal nucleus of the accessory optic tractMTNCR3MPTPPBSIL-1βDATEPO6-HydroxydopamineGFAPALBROS - ROSAlbumin - آلبومینerythropoietin - اریتروپویتینRecombinant human erythropoietin - اریتروپویتین بازآفرینی انسانیStriatum - استریاتومinflammation - التهاب( توروم) Dopamine transporter - انتقال دهنده دوپامینimmunoreactive - ایمنی فعالImmunocytochemistry - ایمونوسیتوشیمیinterleukin-1beta - اینترلوکین-1 بتاParkinson’s disease - بیماری پارکینسونANOVA - تحلیل واریانس Analysis of variancesubstantia nigra - توده سیاهtumor necrosis factor-alpha - تومور نکروز عامل آلفاtyrosine hydroxylase - تیروزین هیدروکسیلازrhEPO - رپوTNF-α - فاکتور نکروز توموری آلفاmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیNeuroprotection - محافظت نورونی یا محافظت از عصبphosphate-buffered solution - محلول بافر فسفاتcomplement receptor type 3 - نوع گیرنده مکمل 3Nitric oxide - نیتریک اکسیدGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease](/preview/png/4342660.png)
چکیده انگلیسی
Erythropoietin (EPO), a hematopoietic cytokine, has recently been demonstrated to protect nigral dopaminergic neurons in a mouse model of Parkinson's disease (PD). In the present study, we tested the hypothesis that recombinant human erythropoietin (rhEPO) could protect dopaminergic neurons and improve neurobehavioral outcome in a rat model of PD. rhEPO (20 units in 2 μl of vehicle) was stereotaxically injected into one side of the striatum. 6-Hydroxydopamine (6-OHDA) was injected into the same side 1 day later. Another group of rats received rhEPO (5000 u/kg, i.p.) daily for 8 days, and unilateral injection of 6-OHDA in the striatum 3 days after systemic administration of rhEPO. We observed that intrastriatal administration, but not systemic administration of rhEPO significantly reduced the degree of rotational asymmetry. The rhEPO-treated rats also showed an improvement in skilled forelimb use when compared with control rats. The number of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in the ipsilateral substantia nigra (SN) was significantly larger in intrastriatal rhEPO-treated rats than that in control rats. TH-IR fibers in the 6-OHDA-lesioned striatum were also increased in the intrastriatal rhEPO-treated rats when compared with control rats. In addition, there were lower levels of expression of major histocompatibility complex (MHC) class II antigens and a smaller number of activated microglia in the ipsilateral SN in intrastriatal rhEPO-treated rats than that in control rats at 2 weeks, suggesting that intrastriatal injection of rhEPO attenuated 6-OHDA-induced inflammation in the ipsilateral SN. Our results suggest that intrastriatal administration of rhEPO can protect nigral dopaminergic neurons from cell death induced by 6-OHDA and improve neurobehavioral outcome in a rat model of PD. Anti-inflammation may be one of mechanisms responsible for rhEPO neuroprotection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 146, Issue 3, 25 May 2007, Pages 1245-1258
Journal: Neuroscience - Volume 146, Issue 3, 25 May 2007, Pages 1245-1258
نویسندگان
Y.-Q. Xue, L.-R. Zhao, W.-P. Guo, W.-M. Duan,