کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342679 | 1295884 | 2006 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain
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کلمات کلیدی
ACTHHeteronuclear RNACRHROIhnRNASSCVPMIn situ hybridization - Hybridization در محلstandard saline citrate - استاندارد سدیم سیتراتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancelateral septum - سپتوم جانبیPVN - مالیات بر ارزش افزودهHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالregion of interest - منطقه مورد نظرHPA - میلی بار یا هکتوپاسکالparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسadrenocorticotropic hormone - هورمون adrenocorticotropiccorticotrophin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینhypothalamus–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالImmediate early genes - ژنهای سریع و سریعMineralocorticoid receptor - گیرنده مینرالوکورتیکوئید glucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain](/preview/png/4342679.png)
چکیده انگلیسی
Rats repeatedly exposed to restraint show a reduced hypothalamic-pituitary-adrenal axis response upon restraint re-exposure. This hypothalamic-pituitary-adrenal axis response habituation to restraint does not generalize to other novel stressors and is associated with a decrease in stress-induced c-fos expression in a number of stress-reactive brain regions. We examined whether habituation to repeated restraint is also associated with adaptation of immediate early gene expression in brain regions that process and relay primary sensory information. These brain regions may not be expected to show gene expression adaptation to repeated restraint because of their necessary role in experience discrimination. Rats were divided into a repeated restraint group (five 1-hour daily restraint sessions) and an unstressed group (restraint naïve). On the sixth day rats from each group were either killed with no additional stress experience or at 15, 30 or 60 min during restraint. Immediate early gene expression (corticotrophin-releasing hormone heteronuclear RNA, c-fos mRNA, zif268 mRNA) was determined by in situ hybridization. A reduction in stress-induced hypothalamic-pituitary-adrenal axis hormone secretion (plasma corticosterone and adrenocorticotropic hormone) and immediate early gene expression levels in the paraventricular nucleus of the hypothalamus, the lateral septum and the orbital cortex was observed in repeated restraint as compared with restraint naïve animals. This reduction was already evident at 15 min of restraint. Unexpectedly, we also found in repeated restraint rats a reduction in restraint-induced c-fos expression in primary sensory-processing brain areas (primary somatosensory cortex, and ventroposteriomedial and dorsolateral geniculate nuclei of thalamus). The overall levels of hippocampal mineralocorticoid receptor heteronuclear RNA or glucocorticoid receptor mRNA were not decreased by repeated restraint, as may occur in response to severe chronic stress. We propose that repeated restraint leads to a systems-level adaptation whereby re-exposure to restraint elicits a rapid inhibitory modulation of primary sensory processing (i.e. sensory gating), thereby producing a widespread attenuation of the neural response to restraint.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 138, Issue 4, 2006, Pages 1067-1081
Journal: Neuroscience - Volume 138, Issue 4, 2006, Pages 1067-1081
نویسندگان
M. Girotti, T.W.W. Pace, R.I. Gaylord, B.A. Rubin, J.P. Herman, R.L. Spencer,