کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343466 1615101 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain
چکیده انگلیسی


• Maternal binge alcohol consumption altered a lot of gene expression in the developing fetal brain.
• Fetal hippocampus is much more venerable to binge alcohol than forebrain.
• Maternal binge alcohol consumption reduced the Nfia gene expression and this reduction correlated to Nmda receptors.
• Nfia-target genes were also altered by binge alcohol in fetal hippocampus.

The objective of the present study was to investigate the changes in gene expression in the fetal brain (forebrain and hippocampus) caused by maternal binge alcohol consumption. Pregnant C57BL/6J mice were treated intragastrically with distilled phosphate-buffered saline (PBS) or ethanol (2.9 g/kg) from embryonic day (ED) 8–12. Microarray analysis revealed that a significant number of genes were altered at ED 18 in the developing brain. Specifically, in hippocampus, nuclear factor one alpha (Nfia) and three N-methyl-d-aspartate (Nmda) receptors (Nmdar1, Nmdar2b, and Nmdar2d) were down-regulated. The transcription factor Nfia controls gliogenesis, cell proliferation and Nmda-induced neuronal survival by regulating the expression of target genes. Some of the Nfia-target gene (Aldh1a, Folh1, Gjb6, Fgf1, Neurod1, Sept4, and Ntsr2) expressions were also altered as expected. These results suggest that the altered expression of Nfia and Nmda receptors may be associated with the etiology of fetal alcohol syndrome (FAS). The data presented in this report will contribute to the understanding of the molecular mechanisms associated with the effects of alcohol in FASD individuals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 598, 26 June 2015, Pages 73–78
نویسندگان
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