Differential molecular chaperone response associated with various mouse adapted scrapie strains

► Molecular chaperones (MCs) such as HSPs and Grps are involved in prion diseases. ► Various mouse adapted scrapie strains produce differential MCs response. ► Amyloidogenic and non-amyloidogenic prion strains engage MCs differently. ► MCs response in amyloidogenic prion strains and APPPS1-21 AD Tg mice is similar.