Repeated carbenoxolone injections during late pregnancy alter Snk-SPAR and PSD-95 expression in the hippocampus of rat pups

► Fetal exposure to glucocorticoid has long term effects on glutamatergic system. ► Carbenoxolone (Cbx) models prenatal stress by increasing glucocorticoid levels. ► We examine effects of Cbx on scaffolding proteins of NMDA receptors. ► Cbx causes a decrease in SPAR and PSD-95 but an increase in Snk. ► Alteration of Snk-SPAR pathway may influence age related memory deficits.