کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346118 | 1296772 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: A biomarker of blood-cerebrospinal fluid barrier permeability
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: A biomarker of blood-cerebrospinal fluid barrier permeability Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: A biomarker of blood-cerebrospinal fluid barrier permeability](/preview/png/4346118.png)
چکیده انگلیسی
The blood-brain barrier, the blood-cerebrospinal fluid barrier (BCB) and other specialized brain barriers are increasingly recognized as a major obstacle to the treatment of most brain disorders. The impairment of these barriers has been implicated in neuropathology of several diseases, such as autism, ischemia, multiple sclerosis and Alzheimer disease. This dual function of the blood-neural barriers points out the importance and need for the development of techniques that can evaluate the nature and level of their integrity. Here we report the discovery of CSF secretory Ca2+-dependent phospholipase A2 (sPLA2) activity as a measure of BCB permeability. Lumbar CSF from BCB impaired (n = 26), multiple sclerosis (n = 18) and healthy control (n = 32) cases was analyzed using both a newly developed continuous fluorescence assay for CSF sPLA2 activity and CSF/Serum albumin ratio (QAlb), the most common and established method to evaluate BCB permeability. While both measurements showed no significant differences between multiple sclerosis and age-matched normal healthy cases, they were highly correlated. Though the CSF sPLA2 activity and QAlb had over 95% agreement, the former was found to be more sensitive than the latter in measuring low levels of BCB impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 478, Issue 3, 12 July 2010, Pages 179-183
Journal: Neuroscience Letters - Volume 478, Issue 3, 12 July 2010, Pages 179-183
نویسندگان
Sonia Chalbot, Henrik Zetterberg, Kaj Blennow, Tormod Fladby, Inge Grundke-Iqbal, Khalid Iqbal,