کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346773 | 1296803 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amelioration of cognitive ability in senescence-accelerated mouse prone 8 (SAMP8) by intra-bone marrow-bone marrow transplantation
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کلمات کلیدی
MSCsHO-1SAMP8Heme oxygenase-1BMCsHSCsSAMR1Alzheimer's disease - بیماری آلزایمرCNS - دستگاه عصبی مرکزیMesenchymal stem cells - سلول های بنیادی مزانشیمیHemopoietic stem cells - سلول های بنیادی هموپاتیbone marrow-derived cells - سلول های مشتق شده از مغز استخوانcentral nervous system - سیستم عصبی مرکزیescape latency - فرار از تأخیرwater maze - ماز آبsenescence-accelerated mouse prone 8 - موش های سالمندی شتابدار 8
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Amelioration of cognitive ability in senescence-accelerated mouse prone 8 (SAMP8) by intra-bone marrow-bone marrow transplantation Amelioration of cognitive ability in senescence-accelerated mouse prone 8 (SAMP8) by intra-bone marrow-bone marrow transplantation](/preview/png/4346773.png)
چکیده انگلیسی
Bone marrow cells (BMCs) can increase the number of activated microglias, which play a central role in the inflammatory response in Alzheimer's disease (AD). Senescence-accelerated mouse (SAM) prone 8 (SAMP8) are widely used in various experiments because of cognitive deficits observed with age. In the present study, 4-month-old SAMP8 were reconstituted with BMCs of C57BL/6 mice by intra-bone marrow-bone marrow transplantation (IBM-BMT), which can reconstitute both donor-derived hemopoietic stem cells and mesenchymal stem cells. Three months after IBM-BMT, the impairment of spatial memory in SAMP8 was found to be ameliorated after analyzing the results of the water maze test. Although IL-1β, IL-6 and iNOS increased and TGF-β decreased in 7 M SAMP8, IL-1β, IL-6 and iNOS decreased while TGF-β increased after IBM-BMT by RT-PCR. Moreover, oxidative stress-related heme oxygenase-1 (HO-1) increased in 7 M SAMP8, but significantly decreased after IBM-BMT. In conclusion, this is the first report suggesting that the impaired cognitive ability of SAMP8 is ameliorated by IBM-BMT. It seems likely that decreases in IL-1β, IL-6, iNOS and HO-1 are a result of the development of donor-derived BMCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 465, Issue 1, 6 November 2009, Pages 36-40
Journal: Neuroscience Letters - Volume 465, Issue 1, 6 November 2009, Pages 36-40
نویسندگان
Ming Li, Muneo Inaba, Kequan Guo, Nader G. Abraham, Susumu Ikehara,