کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347922 | 1615178 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death](/preview/png/4347922.png)
Massive neuronal activation by glutamate can result in an excessive rise in cytoplasmic calcium, a process ultimately leading to neuronal death. We have investigated the role of the transient receptor potential channel 1 (TRPC1) in mediating glutamate-induced neuron death. We show that 2-APB (a blocker of store-operated Ca2+ entry) dramatically reduces glutamate-induced cell death in hippocampal organotypic slice cultures and that glutamate-induced toxicity is accompanied by an increase in TRPC1 expression. RNAi mediated knock-down of TRPC1 in slice cultures prevented glutamate-induced cell death, indicating that TRPC1 plays a prominent role in calcium entry following exposure to glutamate. Thus, TRPC1 may represent a promising target for pharmacological interventions to prevent or reduce glutamate-induced neuronal damage.
Journal: Neuroscience Letters - Volume 446, Issues 2–3, 3 December 2008, Pages 117–122