کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4348938 | 1296914 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sema4D-plexin-B1 implicated in regulation of dendritic spine density through RhoA/ROCK pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sema4D-plexin-B1 implicated in regulation of dendritic spine density through RhoA/ROCK pathway Sema4D-plexin-B1 implicated in regulation of dendritic spine density through RhoA/ROCK pathway](/preview/png/4348938.png)
چکیده انگلیسی
Plexin-B1, Sema4D receptor, mediates retraction and extension signals in axon guidance by associating with PDZ-containing Rho guanine nucleotide exchange factors (PDZ-RhoGEFs) which can activate a small Rho GTPase RhoA. RhoA is implicated in spine formation by rearranging actin cytoskeleton. Exogenous application of Sema4D to cultured neurons caused activation of RhoA, increase of spine density and changes in spine shape. Sema4D-induced changes in spine density were blocked by either Rho-kinase (a downstream of RhoA, ROCK) inhibitor Y-27632 or by overexpression of plexin-B1 mutant lacking the C-terminus which no longer associates with PDZ-RhoGEFs. This study suggests that Sema4D-plexin-B1 play a crucial role in spine formation by regulating RhoA/ROCK pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 428, Issue 1, 20 November 2007, Pages 1-6
Journal: Neuroscience Letters - Volume 428, Issue 1, 20 November 2007, Pages 1-6
نویسندگان
Xianzong Lin, Mariko Ogiya, Mizue Takahara, Wataru Yamaguchi, Tatsuo Furuyama, Hidekazu Tanaka, Masaya Tohyama, Shinobu Inagaki,