کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349399 | 1296939 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated plasma N-terminal ProBNP levels in unmedicated patients with major depressive disorder
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
There is considerable evidence that cardiovascular diseases are more prevalent in patients with major depressive disorder (MDD). Secretion of N-terminal pro-B-type natriuretic peptide (NT-proBNP) increases in several cardiac illnesses, making this neurohormone a reliable diagnostic and prognostic biomarker of cardiovascular risk. We measured plasma NT-proBNP levels in the following three groups of subjects free of overt cardiovascular disease: unmedicated patients with MDD (n = 40), unmedicated patients with schizophrenia (n = 44), and normal control subjects (n = 42). The severity of depressive symptoms was rated using the Hamilton Depression Rating Scale (HAMD). Plasma NT-proBNP levels were assayed by ELISA. Plasma NT-proBNP levels were significantly higher in the MDD group (median: 217.1 pmol/L; interquartile range: 179.4-277.1 pmol/L) than in patients with schizophrenia (175.7 pmol/L [139.0-218.9]; P < 0.05) or in the control group (158.9 pmol/L [98.3-212.1]; P < 0.001). Among patients with MDD, there was a significant positive correlation (Spearman's rank correlation = 0.422, P = 0.008) between plasma NT-proBNP and HAMD scores. Altogether, our results indicate that elevated NT-proBNP levels may play a role in linking MDD with increased cardiovascular risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 417, Issue 3, 7 May 2007, Pages 322-325
Journal: Neuroscience Letters - Volume 417, Issue 3, 7 May 2007, Pages 322-325
نویسندگان
Pierluigi Politi, Piercarlo Minoretti, Noemi Piaggi, Natascia Brondino, Enzo Emanuele,