کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4349413 1296940 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Japanese encephalitis virus infection decrease endogenous IL-10 production: Correlation with microglial activation and neuronal death
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Japanese encephalitis virus infection decrease endogenous IL-10 production: Correlation with microglial activation and neuronal death
چکیده انگلیسی
The anti-inflammatory cytokine interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease, meningitis, and the behavioral changes that occur during bacterial infections. Expression of IL-10 is critical during the course of most major diseases in the CNS and promotes survival of neurons and all glial cells in the brain by blocking the effects of proinflammatory cytokines and by promoting expression of cell survival signals. In order to assess functional importance of this cytokine in viral encephalitis we have exploited an experimental model of Japanese encephalitis (JE). We report for the first time that in Japanese encephalitis, there is a progressive decline in level of IL-10. The extent of progressive decrease in IL-10 level following viral infection is inversely proportional to the increase in the level of proinflammatory cytokines as well as negative consequences that follows viral infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 420, Issue 2, 13 June 2007, Pages 144-149
نویسندگان
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