کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349572 | 1296947 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increase of ceramide monohexoside and dipalmitoyl glycerophospholipids in the brain of Zellweger syndrome
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کلمات کلیدی
ZS, Zellweger syndromeCMH, ceramide monohexosideCNS, central nervous system - CNS، سیستم عصبی مرکزیSM, sphingomyelin - SM، sphingomyelinTLC, thin layer chromatography - TLC، کروماتوگرافی لایه نازکPS, phosphatidylserine - فسفاتیدیل سرینPC, phosphatidylcholine - فسفاتیدیل کولینHPLC, high-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The lipid composition and molecular species of phospholipids were examined in the brain of a patient with Zellweger syndrome (ZS), and were compared with those of control infants. In the cerebral gray matter of the ZS patient, the amounts of ceramide monohexoside and cholesterol ester were larger than those of controls. By contrast, the amount of ceramide monohexoside in the white matter was smaller in the ZS patient than that in the age-matched control. Although the amount of phosphatidylcholine (PC) plus phosphatidylserine (PS) was the same, dipalmitoyl PC and PS were increased in both the gray and white matter of the ZS cerebrum. These alterations in the molecular species of brain lipids may play crucial roles in the pathogenesis of ZS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 417, Issue 2, 1 May 2007, Pages 165–170
Journal: Neuroscience Letters - Volume 417, Issue 2, 1 May 2007, Pages 165–170
نویسندگان
Makiko Saitoh, Yoichi Sakakihara, Masashi Mizuguchi, Masayuki Itoh, Sachio Takashima, Masao Iwamori, Shigehiko Kamoshita, Takashi Igarashi,