کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349597 | 1296948 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SB203580 enhances interleukin-1 receptor antagonist gene expression in IFN-γ-stimulated BV2 microglial cells through a composite nuclear factor-κB/PU.1 binding site
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring antagonist of IL-1α and IL-1β binding to the IL-1 receptors and alleviates various inflammatory reactions. Therefore, the upregulation of IL-1ra expression is important for preventing and/or treating inflammatory diseases including many neurodegenerative diseases. This study found that SB203580, which is generally known as a p38 MAP kinase inhibitor and an anti-inflammatory agent, increased the level of IL-1ra expression in IFN-γ-stimulated BV2 microglial cells. This effect is believed to occur through the inhibition of protein kinase B (PKB), independently of the p38 MAP kinase pathways. Further mechanistic studies using an IL-1ra promoter revealed that a composite NF-κB/PU.1 binding site plays an important role in this SB203580-mediated upregulation of IL-1ra. Considering that IFN-γ is a major stimulator of the innate and adaptive immune responses, the upregulation of anti-inflammatory IL-1ra expression by SB203580 in the IFN-γ-stimulated microglia might provide a new therapeutic modality for various inflammatory diseases of the central nervous system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 416, Issue 2, 12 April 2007, Pages 169-174
Journal: Neuroscience Letters - Volume 416, Issue 2, 12 April 2007, Pages 169-174
نویسندگان
Jin-Sun Park, Soo-Hyun Jung, Hyemyung Seo, Hee-Sun Kim,