کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349744 | 1296955 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma](/preview/png/4349744.png)
چکیده انگلیسی
Recent epidemiological studies raise the possibility that individuals with occupational exposure to low frequency (50-60 Hz) electromagnetic fields (LF-EMF), are at increased risk of Alzheimer's disease (AD). However, the mechanisms through which LF-EMF may affect AD pathology are unknown. We here tested the hypothesis that the exposure to LF-EMF may affect amyloidogenic processes. We examined the effect of exposure to 3.1 mT 50 Hz LF-EMF on Aβ secretion in H4 neuroglioma cells stably overexpressing human mutant amyloid precursor protein. We found that overnight exposure to LF-EMF induces a significant increase of amyloid-beta peptide (Aβ) secretion, including the isoform Aβ 1-42, without affecting cell survival. These findings show for the first time that exposure to LF-EMF stimulates Aβ secretion in vitro, thus alluding to a potential link between LF-EMF exposure and APP processing in the brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 418, Issue 1, 11 May 2007, Pages 9-12
Journal: Neuroscience Letters - Volume 418, Issue 1, 11 May 2007, Pages 9-12
نویسندگان
Elda Del Giudice, Fabrizio Facchinetti, Valentina Nofrate, Pasquale Boccaccio, Tullio Minelli, Mauro Dam, Alberta Leon, Giuliano Moschini,