کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4349956 1296965 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists
چکیده انگلیسی
Activin A levels are elevated in the cerebrospinal fluid (CSF) of patients with meningitis and in the sera of patients with sepsis. The source(s) of the elevated concentrations of activin A in CSF and serum have not yet been discovered. Here we demonstrate that primary mouse microglial cells and peritoneal macrophages release activin A after treatment with agonists of Toll-like receptor (TLR) 2, 4, and 9. These findings provide further evidence for a role of activin in the innate immune response and suggest that microglial cells and macrophages are a source of elevated activin A concentrations observed in the CSF during bacterial meningitis and in the systemic circulation during sepsis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 413, Issue 3, 21 February 2007, Pages 241-244
نویسندگان
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