کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350224 1296978 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
APP23 mice display working memory impairment in the plus-shaped water maze
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
APP23 mice display working memory impairment in the plus-shaped water maze
چکیده انگلیسی

Alzheimer's disease (AD) patients typically present short-term memory deficits, before long-term memory capacity declines with disease progression. Several studies have described learning and memory deficits in the APP23 mouse model. Our group reported a decline of learning and memory capacities from the age of 3 months onwards using a hidden-platform Morris water maze (MWM). The aim of the present study was to evaluate working and reference memory in APP23 mice in the same plus-shaped water maze. The transgenic mice had slower learning curves; however, consolidation of the learned information appeared intact in this learning paradigm. This report demonstrates impairment of working memory in this transgenic Alzheimer model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 407, Issue 1, 16 October 2006, Pages 6–10
نویسندگان
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