کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350413 1615188 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
چکیده انگلیسی

Stress response is an important neuroendocrine function. Overt or prolonged stress hormone secretion can lead to various disease states. The hippocampus plays an important role in the negative feedback onto the major player in the stress response, the hypothalamo-pituitary-adrenal axis. The transcription factor c-Fos is activated in the hippocampus following a number of stressors, including restraint stress. To determine whether c-fos modulates stress response, we previously generated mutant mice carrying a hippocampal mutation of the c-fos gene. In the current study, we found that female mutant mice display lower anxiety-like behavior than female wild-type mice in the elevated plus maze, whereas male mice are apparently normal. While both male and female mutant mice exhibit normal diurnal glucocorticoid (CORT) production and normal responses to acute restraint stress, female mutant mice habituated faster than female wild-type mice in response to chronic restraint stress. These findings suggest that hippocampal c-fos plays a role in gender-dependent response to stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 403, Issues 1–2, 31 July 2006, Pages 125–130
نویسندگان
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