کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350647 1615189 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats
چکیده انگلیسی
The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 402, Issues 1–2, 10 July 2006, Pages 25-29
نویسندگان
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