کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350808 1615192 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain
چکیده انگلیسی

KCNQ-type potassium channels generate the so-called M-current regulating excitability in many neurons. Mutations in KCNQ2/KCNQ3 channels can cause benign familial neonatal convulsions (BFNC). We describe the immunohistochemical staining of adult and developing mouse brain using an antibody directed against the N-terminus of KCNQ3 channels (KCNQ3N). A widespread KCNQ3N immunoreactivity predominantly of neuropil but also of somata was detected in different regions of the adult mouse brain, in particular in the hippocampus, cortex, thalamus and cerebellum. This staining pattern appeared gradually and became more intense during development. In the pyramidal cell layer of the hippocampus, the immunoreactivity changed from a more somatic to a neuropil staining during development. These changes during maturation might be related to the age-dependent phenotype of BFNC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 400, Issues 1–2, 29 May 2006, Pages 101–104
نویسندگان
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